PEG-MGF Peptide
MGF is an acronym for Mechano Growth Factor, a research peptide that scientists consider to belong to the class of IGF-1 (insulin-like growth factor) family.(1) An isoform of IGF-1, MGF is also known as IGF-1Ec, and is believed to primarily be produced in the liver.(2) The IGF-1 gene appears to undergo transcription and may generate the three mRNA isoforms: IGF-1Ea, IGF-1Eb, and IGF-1Ec. This indicates that MGF (or IGF-1Ec) may be identical to IGF-1 but with a different E domain. Synthesis of each isoform appears to possess specific functions in different tissues as a response to diverse stimuli.
PEG-MGF, or polyethylene glycol (PEG)-ylated MGF, is a synthetic form of MGF. Pegylation connects polyethylene glycol (PEG) to another compound to alter its structure. Scientists consider that MGF by itself may have a short half-life; however, once bound with PEG, the half-life may be extended by some days.
Research studies posit that PEG IGF-1 may be more impactful than recombinant IGF-1 for muscle cell regeneration and improving muscle function. The main reasoning was attributed to the hypothesis that PEG may not easily bind with any other compounds, and may thereby lead to delayed clearance. In addition, modifying the C terminus of IGF-1 with the addition of PEG may increase the peptide’s potential impact on tissues.(3)
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