Sermorelin GHRP-2

Description

Sermorelin & GHRP-2 Blend
Sermorelin is a research peptide made of 29 amino acids that is a truncated version of the full 44-aa length endogenous Growth Hormone-Releasing Hormone (GHRH). Sermorelin is considered the shortest functional analogue that contains the first 29 amino acids, and it is also amidated at the C-terminus. According to research by Clark et al., the peptide appears to retain its affinity to the GHRH receptors found in pituitary cells and activate them.(1) Thus, Sermorelin is considered a GHRH analog. GHRH receptors are the main receptors on pituitary cells that are considered to play a role in the synthesis of growth hormone.
Research by Berlanga-Acosta et al. describes GHRP-2 as a fully synthetic hexapeptide, developed from earlier GHRPs such as GHRP-6 and ultimately based on modified enkephalins (endogenous opioid pentapeptides).(2) It is engineered to favor growth hormone release rather than opioid activity, apparently by targeting ghrelin (growth hormone secretagogue) receptors instead of classical opioid receptors.
Because GHRP-2 and related GHRPs share this receptor system, they are broadly referred to as growth hormone secretagogues (GHSs). Researchers suggest that by targeting different pituitary receptors with the same potential, peptides like Sermorelin and GHRP-2 may have synergistic actions. Future research should elucidate this more thoroughly.